Comedy legends Billy Crystal and Bette Midler play Artie and Diane Decker, who are called in by their daughter (Marisa Tomei) to help care for their three grandkids. When their old-school parenting methods collide with their daughter's new-school ways, the once-orderly household spins out of control.

Alice demande a ses parents, Artie et Diane, de venir prendre soin de leurs trois petits-enfants pendant une fin de semaine. Lorsque les methodes d'education "de la vieille ecole" des grands-parents se heurtent a celles plus modernes de leur fille, la maisonnee devient tout a coup incontrolable.